DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells
Identification
- Public canonical key
- radar:r-218bb2cd9e450bea3c47d576bbfaccca
- Authors
- Jai Meyers · Lashika Weerakoon · Vinitha N. Ragavan · Natalia Jarzebska · Roman N Rodionov · Arduino Aleksander Mangoni · Julie-Ann Hulin · Sara Tommasi
- Reported year
- 2026
- Reported language
- en
- Source type
- article
- First detected
- 2026-11-13T12:42:57.722431+00:00
- Last metadata observation
- 2026-11-13T12:42:57.722431+00:00
- Last HTTP verification
- Not checked
Institutions reported by the source
Flinders University · Technische Universität Dresden · Flinders Medical Centre
Reported affiliation countries
AU · DE
Documentary abstract — original language
The overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1) and 2 (DDAH2) has been associated with several types of cancer. Specifically, DDAH1 has been shown to play a critical role in the establishment of a vascular network by tumour cells, vasculogenic mimicry (VM), in triple negative breast cancer (TNBC). In turn, VM favours TNBC progression and is associated with poor patient prognosis. DDAH1 is well characterised in its capacity to metabolise asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor. By contrast, DDAH2 is incapable of metabolising ADMA, and its ADMA-independent functions and role in TNBC are unknown. In an in vitro MDA-MB-231 TNBC cell model, CRISPR-Cas9 knockout and siRNA knockdown of either DDAH1 or DDAH2 significantly reduced VM. This effect was accompanied by a significant reduction in proliferation, migration, invasion, and Vascular endothelial growth factor A (VEGF-A) secretion. These results suggest ADMA-independent mechanisms for DDAH2 in the occurrence of VM and identify DDAH2 as a novel therapeutic target in TNBC.
Identifiers
- OPENALEX
- https://openalex.org/W7167971051
- DOI
- 10.1016/j.biopha.2026.119759
- PMID
- https://pubmed.ncbi.nlm.nih.gov/42430838
Documentary context
- Documentary family
- article
- Source-reported types
- article
- Publishers
- Elsevier BV
Entity mentions are not evidence of legal recognition. Jurisdiction studied is separate from author affiliation country.
Sources
OpenAlex · Record 1
Cite this reference
Jai Meyers; Lashika Weerakoon; Vinitha N. Ragavan; Natalia Jarzebska; Roman N Rodionov; Arduino Aleksander Mangoni; Julie-Ann Hulin; Sara Tommasi. DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells. 2026. https://doi.org/10.1016/j.biopha.2026.119759
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APA, Chicago, ISO 690: bibliographic formats using available fields. OSCOLA / Bluebook: structured data only; full legal citation compliance is not claimed without verification of required elements.
- APA
- Jai Meyers; Lashika Weerakoon; Vinitha N. Ragavan; Natalia Jarzebska; Roman N Rodionov; Arduino Aleksander Mangoni; Julie-Ann Hulin; Sara Tommasi. (2026). DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells. https://doi.org/10.1016/j.biopha.2026.119759
- Chicago
- Jai Meyers; Lashika Weerakoon; Vinitha N. Ragavan; Natalia Jarzebska; Roman N Rodionov; Arduino Aleksander Mangoni; Julie-Ann Hulin; Sara Tommasi. DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells. 2026. https://doi.org/10.1016/j.biopha.2026.119759
- ISO 690
- Jai Meyers; Lashika Weerakoon; Vinitha N. Ragavan; Natalia Jarzebska; Roman N Rodionov; Arduino Aleksander Mangoni; Julie-Ann Hulin; Sara Tommasi. DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells. 2026. https://doi.org/10.1016/j.biopha.2026.119759
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UDTR Global Rights of Nature Legal Library. DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells. Documentary record: https://www.declarationuniverselledesdroitsdelarbre.org/global-rights-of-nature-radar/reference/r-218bb2cd9e450bea3c47d576bbfaccca/ · Last HTTP verification: not performed
Research dossiers and documentary relations
Source roles
Bibliographic / original publication source · https://doi.org/10.1016/j.biopha.2026.119759
An authority link alone does not verify a legal claim. Abstracts and full texts remain subject to their source terms.
Documentary status
Relevance pending
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This identity is not yet included in the Legal Library.