Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory
Identification
- Clé publique
- radar:r-9a2ab8521202e57f99a507dc55b7747a
- Auteurs
- Constantin Munteanu · Anca‐Irina Galaction · Gelu Onose · Marius Alexandru Turnea · Mariana Rotariu
- Année déclarée
- 2025
- Langue déclarée
- en
- Type source
- review
- Première détection
- 2026-11-13T12:44:36.165909+00:00
- Dernière observation des métadonnées
- 2026-11-13T12:44:36.165909+00:00
- Dernière vérification HTTP
- Non effectuée
Institutions déclarées par la source
Clinical Emergency Hospital Bucharest · Grigore T. Popa University of Medicine and Pharmacy · Carol Davila University of Medicine and Pharmacy
Pays d’affiliation déclarés
RO
Résumé documentaire — langue originale
Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function and neurotransmitter release in neuronal circuits. By synthesizing findings from animal and cellular models, we investigate the impacts of enzymatic H2S production and exogenous H2S on excitatory synaptic currents, long-term potentiation, and intracellular calcium signaling. Data suggest that H2S interacts directly with NMDA receptor subunits, altering receptor function and modulating neuronal excitability. Simultaneously, H2S promotes the release of neurotransmitters such as glutamate and GABA, shaping synaptic dynamics and plasticity. Furthermore, reports indicate that disruptions in H2S metabolism contribute to cognitive impairments and neurodegenerative disorders, underscoring the potential therapeutic value of targeting H2S-mediated pathways. Although the precise mechanisms of H2S-induced changes in synaptic strength remain elusive, a growing body of evidence positions H2S as a significant regulator of memory formation processes. This review calls for more rigorous exploration into the molecular underpinnings of H2S in synaptic plasticity, paving the way for novel pharmacological interventions in cognitive dysfunction.
Identifiants
- OPENALEX
- https://openalex.org/W4408924998
- DOI
- 10.3390/ijms26073131
- PMID
- https://pubmed.ncbi.nlm.nih.gov/40243915
- PMCID
- https://www.ncbi.nlm.nih.gov/pmc/articles/11988931
Repères documentaires
- Famille documentaire
- unknown
- Types déclarés par les sources
- review
- Éditeurs
- Multidisciplinary Digital Publishing Institute
Les mentions d’entités ne constituent pas une preuve de reconnaissance juridique. La juridiction étudiée est distincte du pays d’affiliation des auteurs.
Sources
OpenAlex · Document 1
Citer cette référence
Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory. 2025. https://doi.org/10.3390/ijms26073131
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- APA
- Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. (2025). Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory. https://doi.org/10.3390/ijms26073131
- Chicago
- Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory. 2025. https://doi.org/10.3390/ijms26073131
- ISO 690
- Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory. 2025. https://doi.org/10.3390/ijms26073131
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Source bibliographique / publication d’origine · https://doi.org/10.3390/ijms26073131
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