Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones
Identification
- Public canonical key
- radar:r-ba5c8fabff32b7a20757cfa743711a8c
- Authors
- Marcos Roberto Scheide · Tiago Tizziani · Gabriella B. Souza · Francisco F. de Assis · Eufrânio N. da Silva Júnior · Tainá Larissa Lubschinski · Ziliani S. Buss · Paula Giarola Fragoso de Oliveira · Bianca Klafke Beck · Eduardo Monguilhott Dalmarco · Bibiana Paula Dambrós · Mário Steindel · Marcus T. Scotti · Louis P. Sandjo · Antonio Luiz Braga
- Reported year
- 2025
- Reported language
- en
- Source type
- article
- First detected
- 2026-11-14T01:59:53.617360+00:00
- Last metadata observation
- 2026-11-14T01:59:53.617360+00:00
- Last HTTP verification
- Not checked
Institutions reported by the source
Universidade Federal de Santa Catarina · Universidade Federal de Minas Gerais · Universidade Federal da Paraíba
Reported affiliation countries
BR
Documentary abstract — original language
Clinical studies on COVID-19 patients revealed among multiple symptoms, uncontrolled production of inflammatory mediators. The current study presents the inhibitory effects of eleven terpenoid derivatives (1–11) and two naphthoquinones (12 and 13) on the main protease (Mpro) of SARS-CoV-2. All the terpenoids and compound 13 displayed weak inhibitory effects while compound 12 showed moderate inhibitory effects of Mpro with IC50 of 50.2 µM. Anti-inflammatory effects against pro-inflammatory mediators produced in LPS-induced lung injury and the cytotoxicity against Vero and THP-1 cell lines of molecules 12 and 13 were also evaluated. Molecules 12 and 13 presented promising anti-inflammatory activity by attenuating the exudation and neutrophil and leukocyte migration.
Identifiers
- OPENALEX
- https://openalex.org/W4414422650
- DOI
- 10.1080/14786419.2025.2562591
- PMID
- https://pubmed.ncbi.nlm.nih.gov/40975863
Documentary context
- Documentary family
- article
- Source-reported types
- article
- Publishers
- Taylor & Francis
Entity mentions are not evidence of legal recognition. Jurisdiction studied is separate from author affiliation country.
Sources
OpenAlex · Record 1
Cite this reference
Marcos Roberto Scheide; Tiago Tizziani; Gabriella B. Souza; Francisco F. de Assis; Eufrânio N. da Silva Júnior; Tainá Larissa Lubschinski; Ziliani S. Buss; Paula Giarola Fragoso de Oliveira; Bianca Klafke Beck; Eduardo Monguilhott Dalmarco; Bibiana Paula Dambrós; Mário Steindel; Marcus T. Scotti; Louis P. Sandjo; Antonio Luiz Braga. Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones. 2025. https://doi.org/10.1080/14786419.2025.2562591
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APA, Chicago, ISO 690: bibliographic formats using available fields. OSCOLA / Bluebook: structured data only; full legal citation compliance is not claimed without verification of required elements.
- APA
- Marcos Roberto Scheide; Tiago Tizziani; Gabriella B. Souza; Francisco F. de Assis; Eufrânio N. da Silva Júnior; Tainá Larissa Lubschinski; Ziliani S. Buss; Paula Giarola Fragoso de Oliveira; Bianca Klafke Beck; Eduardo Monguilhott Dalmarco; Bibiana Paula Dambrós; Mário Steindel; Marcus T. Scotti; Louis P. Sandjo; Antonio Luiz Braga. (2025). Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones. https://doi.org/10.1080/14786419.2025.2562591
- Chicago
- Marcos Roberto Scheide; Tiago Tizziani; Gabriella B. Souza; Francisco F. de Assis; Eufrânio N. da Silva Júnior; Tainá Larissa Lubschinski; Ziliani S. Buss; Paula Giarola Fragoso de Oliveira; Bianca Klafke Beck; Eduardo Monguilhott Dalmarco; Bibiana Paula Dambrós; Mário Steindel; Marcus T. Scotti; Louis P. Sandjo; Antonio Luiz Braga. Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones. 2025. https://doi.org/10.1080/14786419.2025.2562591
- ISO 690
- Marcos Roberto Scheide; Tiago Tizziani; Gabriella B. Souza; Francisco F. de Assis; Eufrânio N. da Silva Júnior; Tainá Larissa Lubschinski; Ziliani S. Buss; Paula Giarola Fragoso de Oliveira; Bianca Klafke Beck; Eduardo Monguilhott Dalmarco; Bibiana Paula Dambrós; Mário Steindel; Marcus T. Scotti; Louis P. Sandjo; Antonio Luiz Braga. Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones. 2025. https://doi.org/10.1080/14786419.2025.2562591
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UDTR Global Rights of Nature Legal Library. Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones. Documentary record: https://www.declarationuniverselledesdroitsdelarbre.org/global-rights-of-nature-radar/reference/r-ba5c8fabff32b7a20757cfa743711a8c/ · Last HTTP verification: not performed
Research dossiers and documentary relations
Source roles
Bibliographic / original publication source · https://doi.org/10.1080/14786419.2025.2562591
An authority link alone does not verify a legal claim. Abstracts and full texts remain subject to their source terms.
Documentary status
Relevance pending
Library
This identity is not yet included in the Legal Library.