Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells
Identification
- Public canonical key
- radar:r-4768dc276f67eb237a2e5d427cf7e002
- Authors
- Constantin Munteanu · Anca‐Irina Galaction · Gelu Onose · Marius Alexandru Turnea · Mariana Rotariu
- Reported year
- 2025
- Reported language
- en
- Source type
- review
- First detected
- 2026-11-13T12:44:36.165909+00:00
- Last metadata observation
- 2026-11-13T12:44:36.165909+00:00
- Last HTTP verification
- Not checked
Institutions reported by the source
Clinical Emergency Hospital Bucharest · Grigore T. Popa University of Medicine and Pharmacy · Carol Davila University of Medicine and Pharmacy
Reported affiliation countries
RO
Documentary abstract — original language
Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells and endothelial cells are particularly susceptible to oxidative damage, which exacerbates vascular aging through cellular senescence, chronic inflammation, and arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), and carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by which H2S, NO, and CO influence vascular smooth muscle and endothelial cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems and combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, and activates antioxidant pathways. NO improves endothelial function, promotes vasodilation, and inhibits platelet aggregation. CO exhibits cytoprotective and anti-inflammatory effects by modulating heme oxygenase activity and ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) and targeted delivery systems show significant promise. Synergistic effects with lifestyle modifications and antioxidant therapies further enhance their therapeutic potential. In conclusion, gasotransmitters hold significant promise as therapeutic agents to combat age-related oxidative stress in vascular cells. Their multifaceted mechanisms and innovative delivery approaches make them potential candidates for treating vascular dysfunction and promoting healthy vascular aging. Further research is needed to translate these findings into clinical applications.
Identifiers
- OPENALEX
- https://openalex.org/W4408036139
- DOI
- 10.3390/ph18030344
- PMID
- https://pubmed.ncbi.nlm.nih.gov/40143122
- PMCID
- https://www.ncbi.nlm.nih.gov/pmc/articles/11946800
Documentary context
- Documentary family
- unknown
- Source-reported types
- review
- Publishers
- Multidisciplinary Digital Publishing Institute
Entity mentions are not evidence of legal recognition. Jurisdiction studied is separate from author affiliation country.
Sources
OpenAlex · Record 1
Cite this reference
Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells. 2025. https://doi.org/10.3390/ph18030344
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- APA
- Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. (2025). Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells. https://doi.org/10.3390/ph18030344
- Chicago
- Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells. 2025. https://doi.org/10.3390/ph18030344
- ISO 690
- Constantin Munteanu; Anca‐Irina Galaction; Gelu Onose; Marius Alexandru Turnea; Mariana Rotariu. Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells. 2025. https://doi.org/10.3390/ph18030344
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UDTR Global Rights of Nature Legal Library. Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells. Documentary record: https://www.declarationuniverselledesdroitsdelarbre.org/global-rights-of-nature-radar/reference/r-4768dc276f67eb237a2e5d427cf7e002/ · Last HTTP verification: not performed
Research dossiers and documentary relations
Source roles
Bibliographic / original publication source · https://doi.org/10.3390/ph18030344
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Documentary status
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